Histones comprise the major protein component of chromatin, the scaffold in which the eukaryotic
genome is packaged, and are subject to many types of post-translational modifications …

… We thank members of the Patel laboratory for their structural contributions to the literature
on aptamer complexes. Funding was provided by NIH GM-54777 and NIH CA-46778. …

Eye health and vision have widespread and profound implications for many aspects of life,
health, sustainable development, and the economy. Yet nowadays, many people, families, …

This release incorporates new features and bug fixes (271 PRs from 48 contributors) since
our last release in October 2021. It adds TensorRT, Edge TPU and OpenVINO support, and …

Abstract Treatment of pediatric acute lymphoblastic leukemia (ALL) is based on the concept
of tailoring the intensity of therapy to a patient's risk of relapse. To determine whether gene …

Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells
or be activated in specific pathological states. The oncogenic RAS-selective lethal small …

Background Understanding potential trajectories in health and drivers of health is crucial to
guiding long-term investments and policy implementation. Past work on forecasting has …

Fiber orientation across the left ventricular myocardial wall has been studied. Specimens
were obtained from 18 dog hearts rapidly fixed in situ in systole, in diastole, and in dilated …

10.7554/eLife.02523.001 Exchange of extracellular cystine for intracellular glutamate by the
antiporter system x c − is implicated in numerous pathologies. Pharmacological agents that …

… (a) the total frequency of IFN-γ-, IL-2- or TNF-producing CD4 + T cells, (c) the frequency of
cells expressing each of the seven possible combinations of IFN-γ, IL-2 and TNF and (d) the …