RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as …

These findings illuminate the mechanistic features of KRAS-mediated chemoresistance and
provide a rationale for exploiting metabolic reprogramming in pancreatic cancer cells to …

The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, …

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling events …

For nearly a decade, the difficulties associated with both the determination and reproducibility
of Ras-dependency indexes (RDIs) have limited their application and further delineation of …

KRAS, the most frequently mutated oncogene in human cancer, produces two isoforms,
KRAS4a and KRAS4b, through alternative splicing. These isoforms differ in exon 4, which …

Human cells harbor a variety of factors that function to block the proliferation of foreign
nucleic acid. The APOBEC3G enzyme inhibits the replication of retroviruses by deaminating …

RAS is a signaling protein associated with the cell membrane that is mutated in up to 30%
of human cancers. RAS signaling has been proposed to be regulated by dynamic …

BackgroundThe HIV Network for Prevention Trials (HIVNET) 012 trial showed that NVP
resistance (NVPR) emerged in some women and children after the administration of single-dose …

Interdependence across time and length scales is common in biology, where atomic interactions
can impact larger-scale phenomenon. Such dependence is especially true for a well-…