Fibrosis is observed in nearly every form of myocardial disease 1 . Upon injury, cardiac
fibroblasts in the heart begin to remodel the myocardium by depositing excess extracellular matrix…

Targeted delivery of drugs is a major challenge in treatment of diverse diseases. Systemically
administered drugs demand high doses and are accompanied by poor selectivity and side …

In the past years, recombinase-based approaches for integrating transgenes into defined
chromosomal loci of mammalian cells have gained increasing attention. This method is …

The original tetracycline system requires two DNA constructs for constitutive expression of the
transactivator and the transactivator-dependent expression of the target gene, respectively…

In colorectal cancer patients, a high density of cytotoxic CD8 + T cells in tumors is
associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/β-catenin-…

This paper describes a new human alveolar epithelial cell line (hAELVi–human Alveolar
Epithelial Lentivirus immortalized) with type I-like characteristics and functional tight junctions, …

Interleukin (IL)‐6 is a pleiotropic cytokine involved in the differentiation and proliferation of
hematopoietic cells. Hepatocytes respond to IL‐6 with the synthesis and secretion of acute‐…

Faithful expression of transgenes in cell cultures and mice is often challenged by locus
dependent epigenetic silencing. We investigated silencing of Tet-controlled expression cassettes …

Background & Aims Hepatitis B virus (HBV) is a major human pathogen restricted to
hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting …

Fundamental research and drug development for personalized medicine necessitates cell
cultures from defined genetic backgrounds. However, providing sufficient numbers of …