Algal fucoidans possess a wide variety of biological activities, including anticoagulation and
antithrombosis, making them potential candidates for clinical use. We assessed the …

Background In estrogen responsive MCF-7 cells, estradiol (E 2 ) binding to ERα leads to
transcriptional regulation of genes involved in the control of cell proliferation and survival. …

We have investigated the signaling pathways underlying muscarinic receptor-induced
calcium oscillations in human embryonic kidney (HEK293) cells. Activation of muscarinic …

Non-alcoholic fatty-liver disease (NAFLD), caused by elevated hepatic lipids, inflammation
and oxidative stress, is the most common liver disease globally. Low molecular weight …

Dynamic nuclear Ca 2+ signals play pivotal roles in diverse cellular functions including gene
transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca …

Background Ischemia reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI)
in both native and transplanted kidneys. The objective of the present study was to evaluate …

Connexin 43 (Cx43)-associated gap junctions form electrical and mechanical conduits
between adjacent ventricular cardiomyocytes, ensuring coordinate electrical excitation and …

Endothelial dysfunction, characterized by impairment of endothelial nitric oxide synthase (eNOS)
and nitric oxide (NO) bioavailability, has been implicated in diabetic cardiovascular …

Diabetic retinopathy (DR) is a hyperglycemia-induced ischemic disorder characterized by
microvascular dysfunction and neovascularization. It is a leading cause of blindness in many …

Interaction between the endoplasmic reticulum (ER)-located stromal interaction molecue1 (STIM1)
and the plasma membrane-located Ca 2+ channel subunit, Orai1, underlies store-…