Background In murine heart failure models and in humans with diabetic‐related heart
hypertrophy, inhibition of phosphodiesterase 5 ( PDE 5) by sildenafil improves cardiac outcomes. …

The parasite Trypanosoma brucei, the causative agent of sleeping sickness, cycles between
an insect and a mammalian host. Here, we investigated the presence of pseudouridines (Ψs…

There are no studies so far linking molecular regulation of lymphangiogenesis and induction
of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor …

G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian
cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at …

Transcription factors (TFs) alter gene expression in response to changes in the environment
through sequence-specific interactions with the DNA. These interactions are best portrayed …

Protein binding to DNA is a fundamental process in gene regulation. Methodologies such as
ChIP-Seq and mapping of DNase I hypersensitive sites provide global information on this …

Because of its all-weather and all-time characteristics, SAR images are particularly effective
to monitor disaster events. When a disaster occurs, the image acquired from a SAR sensor …

Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis
into the normally avascular cornea is incompatible with good vision and, therefore, the …

Recent experimental and clinical data suggest that there is a link between dry eye disease (DED)
and T-cell-mediated immunity. However, whether these immune responses are a …

NK cells have been increasingly reported to be an important effector in autoimmune diseases.
However, nothing is known in this regard in DED, the most common eye pathology, which …