The dynamic interplay between the gut microbiota and autoimmune diseases

H Xu, M Liu, J Cao, X Li, D Fan, Y Xia… - Journal of …, 2019 - Wiley Online Library
The human gut‐resident commensal microbiota is a unique ecosystem associated with
various bodily functions, especially immunity. Gut microbiota dysbiosis plays a crucial role in …

The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment

X Wang, D Fan, X Cao, Q Ye, Q Wang, M Zhang… - Antioxidants, 2022 - mdpi.com
Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to
modified self-antigens and immune system abnormalities, eventually leading to synovitis and …

m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
N6-methyladenosine (m 6 A) methylation is the most universal internal modification in eukaryotic
mRNA. With elaborate functions executed by m 6 A writers, erasers, and readers, m 6 A …

Triptolide modulates TREM-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis

D Fan, X He, Y Bian, Q Guo, K Zheng, Y Zhao… - International Journal of …, 2016 - mdpi.com
Triptolide (TP), an active component isolated from Tripterygiumwilfordii Hook F, has
therapeutic potential against rheumatoid arthritis (RA). However, the underlying molecular …

The effect of triptolide in rheumatoid arthritis: from basic research towards clinical translation

D Fan, Q Guo, J Shen, K Zheng, C Lu, G Zhang… - International journal of …, 2018 - mdpi.com
Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been
shown to exert potent pharmacological effects, especially an immunosuppressive effect in the …

Interactions between gut microbiota and immunomodulatory cells in rheumatoid arthritis

H Xu, H Zhao, D Fan, M Liu, J Cao, Y Xia… - Mediators of …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases caused by
abnormal immune activation and immune tolerance. Immunomodulatory cells (ICs) play a critical …

Pain mechanism in rheumatoid arthritis: from cytokines to central sensitization

Y Cao, D Fan, Y Yin - Mediators of inflammation, 2020 - Wiley Online Library
Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of disease‐…

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

Q Guo, K Zheng, D Fan, Y Zhao, L Li, Y Bian… - Frontiers in …, 2017 - frontiersin.org
Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction (WTD)
in rheumatoid arthritis (RA) through network pharmacology prediction and experimental …

[HTML][HTML] The latest information on the RIPK1 post-translational modifications and functions

Q Wang, D Fan, Y Xia, Q Ye, X Xi, G Zhang… - Biomedicine & …, 2021 - Elsevier
RIPK1 is a protein kinase that simultaneously regulates inflammation, apoptosis, and necroptosis.
It is thought that RIPK1 has separate functions through its scaffold structure and kinase …

Human umbilical mesenchymal stem cells display therapeutic potential in rheumatoid arthritis by regulating interactions between immunity and gut microbiota via the …

X Li, C Lu, D Fan, X Lu, Y Xia, H Zhao, H Xu… - Frontiers in cell and …, 2020 - frontiersin.org
Background Rheumatoid arthritis (RA) is an autoimmune disease that may be associated
with gut microbiota via the aryl hydrocarbon receptor (AhR). Human umbilical mesenchymal …