Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent …
…, R Sundaramoorthi, Y Wang, D Zou… - Journal of medicinal …, 2010 - ACS Publications
In the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors, the T315I
gatekeeper mutant has emerged as resistant to all currently approved agents. This report …
gatekeeper mutant has emerged as resistant to all currently approved agents. This report …
Discovery of brigatinib (AP26113), a phosphine oxide-containing, potent, orally active inhibitor of anaplastic lymphoma kinase
WS Huang, S Liu, D Zou, M Thomas… - Journal of medicinal …, 2016 - ACS Publications
In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic
lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC), secondary mutations …
lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC), secondary mutations …
Design strategy of poly (vinylidene fluoride) membranes for water treatment
The development of facile, benign and energy-efficient water treatment technologies to
produce clean water presents a major societal challenge. Membrane-based separation …
produce clean water presents a major societal challenge. Membrane-based separation …
The potent ALK inhibitor brigatinib (AP26113) overcomes mechanisms of resistance to first-and second-generation ALK inhibitors in preclinical models
…, L Moran, WS Huang, S Liu, D Zou… - Clinical Cancer …, 2016 - aacrjournals.org
Purpose: Non–small cell lung cancers (NSCLCs) harboring ALK gene rearrangements (ALK
+ ) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) …
+ ) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) …
The 2019 novel coronavirus resource.
An ongoing outbreak of a novel coronavirus infection in Wuhan, China since December
2019 has led to 31,516 infected persons and 638 deaths across 25 countries (till 16: 00 on …
2019 has led to 31,516 infected persons and 638 deaths across 25 countries (till 16: 00 on …
Postnatal refinement of peripheral olfactory projections
DJ Zou, P Feinstein, AL Rivers, GA Mathews, A Kim… - Science, 2004 - science.org
Axonal projections from the olfactory epithelium to the olfactory bulb are organized into
glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that …
glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that …
LncBook: a curated knowledgebase of human long non-coding RNAs
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important
biological processes. Although the number of known human lncRNAs has dramatically …
biological processes. Although the number of known human lncRNAs has dramatically …
Functional expression of the olfactory signaling system in the kidney
JL Pluznick, DJ Zou, X Zhang, Q Yan… - Proceedings of the …, 2009 - pnas.org
Olfactory-like chemosensory signaling occurs outside of the olfactory epithelium. We find
that major components of olfaction, including olfactory receptors (ORs), olfactory-related …
that major components of olfaction, including olfactory receptors (ORs), olfactory-related …
EWAS Atlas: a curated knowledgebase of epigenome-wide association studies
Epigenome-Wide Association Study (EWAS) has become increasingly significant in identifying
the associations between epigenetic variations and different biological traits. In this study, …
the associations between epigenetic variations and different biological traits. In this study, …
Dendritic dynamics in vivo change during neuronal maturation
GY Wu, DJ Zou, I Rajan, H Cline - Journal of Neuroscience, 1999 - jneurosci.org
In vivo imaging of optic tectal neurons in the intactXenopus tadpole permits direct observation
of the structural dynamics that occur during dendritic arbor formation. Based on images of …
of the structural dynamics that occur during dendritic arbor formation. Based on images of …