Background Exosomes have emerged as vital biomarkers of multiple cancers and contain
abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used …

Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified
to participate in tumour pathogenesis, acting as a promoter in colorectal cancer …

Incidence of early-onset colorectal cancer (EOCRC), defined by a diagnosed age under 50
years, is increasing, but its heterogeneous etiologies that differ from general CRC remain …

Genome-wide association studies (GWASs) have identified multiple susceptibility loci for
colorectal cancer, but much of heritability remains unexplained. To identify additional …

The development of an effective survival prediction tool is key for reducing colorectal cancer
mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) …

Background The genetic architectures of colorectal cancer are distinct across different
populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR…

BACKGROUND PIWI‐interacting RNAs (piRNAs), which are a novel type of identified small
noncoding RNA (ncRNA), play a crucial role in germline development and carcinogenesis. …

Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory
roles in human cancer biology. By utilizing publicly available lncRNAs expression profiling …

The N6-methyladenosine (m 6 A) modification plays important regulatory roles in gene
expression, cancer occurrence and metastasis. Herein, we aimed to explore the association …

DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B, which affect promoter CpG
methylation status, play a significant role in cancer development. Little is known regarding the …