Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Despite evidence demonstrating the role of β1-integrin in the regulation of cancer cell
proliferation in vitro, the importance of this cell adhesion receptor during the initiation and …

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal
cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial …

Elevated MET receptor tyrosine kinase correlates with poor outcome in breast cancer, yet
the reasons for this are poorly understood. We thus generated a transgenic mouse model …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large
proportion of human breast cancers. Although several studies have implicated FAK as an …

To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice
expressing several phosphotyrosine‐deficient ShcA alleles under the control of their …

Epithelial-mesenchymal transition (EMT) is important in embryonic development and
tumorigenesis. Smad-interacting protein 1 (SIP1) can induce EMT by repressing the transcription of …

Infiltration of C D 8 + T lymphocytes into solid tumors is associated with good prognosis in
various types of cancer, including triple-negative breast cancer (TNBC). However, the …

Immunosurveillance constitutes the first step of cancer immunoediting in which developing
malignant lesions are eliminated by antitumorigenic immune cells. However, the mechanisms …