User profiles for Edison Liu
Edison T LiuThe Jackson Laboratory Verified email at jax.org Cited by 58315 |
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
Comprehensive gene expression patterns generated from cDNA microarrays were correlated
with detailed clinico-pathological characteristics and clinical outcome in an unselected …
with detailed clinico-pathological characteristics and clinical outcome in an unselected …
An oestrogen-receptor-α-bound human chromatin interactome
Genomes are organized into high-level three-dimensional structures, and DNA elements
separated by long genomic distances can in principle interact functionally. Many transcription …
separated by long genomic distances can in principle interact functionally. Many transcription …
Genome-wide analysis of mammalian promoter architecture and evolution
Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…
A global map of p53 transcription-factor binding sites in the human genome
The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is
crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that …
crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that …
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
Perturbations of the p53 pathway are associated with more aggressive and therapeutically
refractory tumors. However, molecular assessment of p53 status, by using sequence analysis …
refractory tumors. However, molecular assessment of p53 status, by using sequence analysis …
[HTML][HTML] c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer
Background The role of molecular markers in predicting the response to treatment of breast
cancer is poorly defined. The Cancer and Leukemia Group B (CALGB) conducted a …
cancer is poorly defined. The Cancer and Leukemia Group B (CALGB) conducted a …
[HTML][HTML] Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …
CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription
Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
…, X Han, L Holmberg, F Huang, S Klaar, ET Liu… - Breast cancer …, 2005 - Springer
Introduction Adjuvant breast cancer therapy significantly improves survival, but overtreatment
and undertreatment are major problems. Breast cancer expression profiling has so far …
and undertreatment are major problems. Breast cancer expression profiling has so far …