KIT gain of function mutations play an important role in the pathogenesis of gastrointestinal
stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of ABL, platelet-…

Methylation of promoter CpG islands in colorectal cancer (CRC) falls into two categories:
age related and cancer specific. Most cancer-specific methylation at CpG islands occurs in a …

We report a new mechanism of aberrant pre-mRNA splicing resulting in constitutive activation
of a mis-spliced oncoprotein (KIT) leading to malignancy (gastrointestinal stromal tumor) in …

Activating mutation in KIT or platelet-derived growth factor-α can lead to gastrointestinal
stromal tumors (GISTs). Eighty-four cases from two institutes were analyzed. Of them, 62 (74%) …

Current evidence suggests that carbonic anhydrase II (CA II) is produced by pancreatic duct
cells but not by pancreatic acinar or islet cells. The aim of this study was to determine …

Conventional chemotherapeutic drugs are ineffective in treatment of gastrointestinal stromal
tumors (GISTs). Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, …

Cooperative team-based activities are changing the nature of work. Current frameworks
provide the necessary base communication and coordination tools but require application …

Elongation factor‐1 (EF‐1) γ is overexpressed in a high proportion of gastrointestinal cancers.
The mechanism of overexpression has not been determined. The purpose of this study …

BACKGROUND & AIMS: The nonspecific cross-reacting antigen (NCA) is a cell adhesion
molecule, and the messenger RNA for NCA is overexpressed in 92% of colorectal carcinomas. …

We have used single-strand conformationalpolymorphism (SSCP) and heteroduplex analysis
to examineDNA from 50 colorectal carcinoma patients coming fromfamilies meeting the …