The adult thymus provides a variety of specialized microenvironments that support and direct
T cell differentiation and selection. In this review, we summarize recent advances in the …

We have discovered that intracellular redox state appears to be a necessary and sufficient
modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-…

Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal
abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N …

Immunoglobulin E (IgE) antibodies are pathogenic in asthma and allergic diseases, but the
in vivo biology of IgE-producing (IgE+) cells is poorly understood. A model of the …

Developing thymocytes are screened for self-reactivity before they exit the thymus, but how
thymocytes scan the medulla for self antigens is unclear. Using two-photon microscopy, we …

Signaling induced through interactions between DSL (Delta, serrate, LAG‐2) ligand‐signaling
cells and Notch‐responding cells influences the developmental fate of a wide variety of …

Little is known about the dynamics of the interactions between thymocytes and other cell
types, as well as the spatiotemporal distribution of thymocytes during positive selection in the …

The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of
Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the …

This paper presents automated methods to quantify dynamic phenomena such as cell–cell
interactions and cell migration patterns from time-lapse series of multi-channel three-…

During thymic development, T cell progenitors undergo positive selection based on the ability
of their T cell Ag receptors (TCR) to bind MHC ligands on thymic epithelial cells. Positive …