[HTML][HTML] A systematic review of nudge theories and strategies used to influence adult health behaviour and outcome in diabetes management

…, S Yoon, LYC Ho, CW Huang, EH Chew… - Diabetes & …, 2020 - Elsevier
Background Diabetes is a chronic disease associated with a variety of complications, and
nudging may be a potential solution to improve diabetes control. Since nudging is a new …

[HTML][HTML] Measurement properties of existing patient-reported outcome measures on medication adherence: systematic review

…, JK Phang, LJY Oo, DV Blalock, EH Chew… - Journal of medical …, 2020 - jmir.org
Background Medication adherence is essential for improving the health outcomes of patients.
Various patient-reported outcome measures (PROMs) have been developed to measure …

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

J Lu, EH Chew, A Holmgren - Proceedings of the national academy of …, 2007 - pnas.org
Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic leukemia
and has potential anticancer activity against a wide range of solid tumors. ATO exerts its …

Inhibition of the human thioredoxin system: a molecular mechanism of mercury toxicity

CML Carvalho, EH Chew, SI Hashemy, J Lu… - Journal of Biological …, 2008 - jbc.org
Mercury toxicity mediated by different forms of mercury is a major health problem; however,
the molecular mechanisms underlying toxicity remain elusive. We analyzed the effects of …

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

EH Chew, AA Nagle, Y Zhang, S Scarmagnani… - Free Radical Biology …, 2010 - Elsevier
Trans-cinnamaldehyde (CA) and its analogs 2-hydroxycinnamaldehyde and 2-benzoyloxycinnamaldehyde
have been reported to possess antitumor activity. CA is also a known Nrf2 …

Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular …

…, FF Gan, SB Shelar, KY Ng, EH Chew - Food and chemical …, 2013 - Elsevier
Ixeris sonchifolia Hance is an herb distributed in northeastern part of China and has been
used by natives to invigorate circulation. In the present study, bioactivity-guided fractionation of …

Functionalized aurones as inducers of NAD (P) H: quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR

CY Lee, EH Chew, ML Go - European journal of medicinal chemistry, 2010 - Elsevier
The chemopreventive potential of functionalized aurones and related compounds as inducers
of NAD(P)H:quinone oxidoreductase 1 (NQO1, EC 1.6.99.2) are described. Several 4,6-…

Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression

H Ling, Y Zhang, KY Ng, EH Chew - Breast cancer research and treatment, 2011 - Springer
Pachymic acid (PA), a lanostane-type triterpenoid derived from Poria cocos, possesses
demonstrated anti-inflammatory and anti-cancer activities. Nonetheless, the biological properties …

Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative …

…, CW Yap, TS Kang, WK Chui, EH Chew - Antioxidants & redox …, 2013 - liebertpub.com
Aims: The role of thioredoxin reductase (TrxR) in tumorigenesis has made it an attractive
anticancer target. A systematic approach for development of novel compounds as TrxR …

Design, synthesis, and biological evaluation of coupled bioactive scaffolds as potential anticancer agents for dual targeting of dihydrofolate reductase and thioredoxin …

HL Ng, X Ma, EH Chew, WK Chui - Journal of Medicinal Chemistry, 2017 - ACS Publications
The dihydrofolate reductase (DHFR) and thioredoxin reductase (TrxR) enzymes are
involved in the process of tumor cell growth and survival. The 4,6-diamino-1,2-dihydro-1,3,5-triazine …