… ' of protein folding 7 . As well as providing a firm conceptual basis for folding, it has shown
that many of the earlier phenomenological descriptions of the folding process are important …

… folding describes this process as a nearly sequential series of discrete intermediates. In
contrast, the energy landscape theory of folding considers folding as … that control protein folding. …

1. THE PROTEIN FOLDING PROBLEM To be biologically active, all proteins must adopt
specific folded three-dimensional structures. Yet the genetic information for the protein specifies …

… folding to the glass transition temperature ratio of 1.6. A simulation of a three-letter code, 27-mer
lattice model gives a picture of the folding mechanism and the folding … fast-folding helical …

… puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict
the … Once regarded as a grand challenge, protein folding has seen great progress in recent …

… folding and to find folding intermediates, which are partially structured states along the “folding …
chain caught in the act of folding would give insights into folding “mechanisms,” the rules …

… folding intermediates. The data available from a variety of proteins point to the existence of
three common stages of folding. 1. … The final stage in folding corresponds to the concerted …

… The terms concentric and similar folding were introduced by van Hise (1896). He also used
parallel folding as a synonym for concentric folding in the sense that in such folding a normal …

… Thus far, our folding rules are based on the properties of native proteins, but more information
about the folding … and for the light shed on the folding process. An understanding of protein …

… involved rocks determine which mechanism of folding will operate. Flexural mechanisms are
… of layering in the folding process decreases. Flexural folding represents a true bending of …