Live face video vs. spoof face video: Use of moiré patterns to detect replay video attacks
With the wide deployment of face recognition systems in applications from border control to
mobile device unlocking, the combat of face spoofing attacks requires increased attention; …
mobile device unlocking, the combat of face spoofing attacks requires increased attention; …
Total synthesis of (−)-macrolactin A
AB Smith, GR Ott - Journal of the American Chemical Society, 1996 - ACS Publications
In 1989 Fenical et al. reported the isolation and planar structures of macrolactins AF, highly
unsaturated macrolides produced in culture by a taxonomically unclassifiable deep-sea …
unsaturated macrolides produced in culture by a taxonomically unclassifiable deep-sea …
Total syntheses of (−)-macrolactin A,(+)-macrolactin E, and (−)-macrolactinic acid: an exercise in Stille cross-coupling chemistry
AB Smith, GR Ott - Journal of the American Chemical Society, 1998 - ACS Publications
The total syntheses of the potent antiviral agent (−)-macrolactin A (1) and two related family
members, (+)-macrolactin E (5) and (−)-macrolactinic acid (7), have been achieved, …
members, (+)-macrolactin E (5) and (−)-macrolactinic acid (7), have been achieved, …
Discovery of clinical candidate CEP-37440, a selective inhibitor of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK)
GR Ott, M Cheng, KS Learn, J Wagner… - Journal of medicinal …, 2016 - ACS Publications
Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized
for metabolic stability. The results from this endeavor not only led to improved metabolic …
for metabolic stability. The results from this endeavor not only led to improved metabolic …
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment
…, MA Fry, NM Urman, SX Atwood, J Roffey, GR Ott… - JCI …, 2017 - pmc.ncbi.nlm.nih.gov
Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating
GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required …
GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required …
CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers
M Cheng, MR Quail, DE Gingrich, GR Ott… - Molecular cancer …, 2012 - aacrjournals.org
Anaplastic lymphoma kinase (ALK) is constitutively activated in a number of human cancer
types due to chromosomal translocations, point mutations, and gene amplification and has …
types due to chromosomal translocations, point mutations, and gene amplification and has …
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and …
Z Lu, GR Ott, R Anand, RQ Liu, MB Covington… - Bioorganic & medicinal …, 2008 - Elsevier
Potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) were
discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino …
discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino …
Multigram Synthesis of the C29− C51 Subunit and Completion of the Total Synthesis of Altohyrtin C (Spongistatin 2)
…, R Scott, MM Claffey, CJ Hayes, GR Ott - Journal of the …, 2003 - ACS Publications
A multigram synthesis of the C29−C51 subunit of altohyrtin C (spongistatin 2) has been
accomplished. Union of this intermediate with the C1−C28 fragment and further elaboration …
accomplished. Union of this intermediate with the C1−C28 fragment and further elaboration …
2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with …
GR Ott, GJ Wells, TV Thieu, MR Quail… - Journal of medicinal …, 2011 - ACS Publications
A novel 2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazine scaffold has been designed as a new
kinase inhibitor platform mimicking the bioactive conformation of the well-known …
kinase inhibitor platform mimicking the bioactive conformation of the well-known …
Technically extended multiparameter optimization (TEMPO): an advanced robust scoring scheme to calculate central nervous system druggability and monitor lead …
AK Ghose, GR Ott, RL Hudkins - ACS Chemical Neuroscience, 2017 - ACS Publications
At the discovery stage, it is important to understand the drug design concepts for a CNS
drug compared to those for a non-CNS drug. Previously, we published on ideal CNS drug …
drug compared to those for a non-CNS drug. Previously, we published on ideal CNS drug …