Background In observational analyses, higher levels of high-density lipoprotein (HDL)
cholesterol have been associated with a lower risk of coronary heart disease events. However, …

Background Patients who have had an acute coronary syndrome are at high risk for recurrent
ischemic cardiovascular events. We sought to determine whether alirocumab, a human …

ContextPatients experience the highest rate of death and recurrent ischemic events during
the early period after an acute coronary syndrome, but it is not known whether early initiation …

We show that when a moving object suddenly reverses direction, there is a brief, synchronous
burst of firing within a population of retinal ganglion cells. This burst can be driven by …

Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …

Background Patients with ischemic stroke or transient ischemic attack (TIA) are at increased
risk for future cardiovascular events despite current preventive therapies. The identification …

We examine whether temporally defined associations play a role in item recognition. The
role of these associations in recall tasks is well known; we demonstrate an important role in …

Understanding a sensory system implies the ability to predict responses to a variety of inputs
from a common model. In the retina, this includes predicting how the integration of signals …

Background— Inflammation promotes acute coronary syndromes and ensuing clinical
complications. Although statins reduce inflammatory markers in asymptomatic adults or in patients …

Background Following acute coronary syndrome (ACS), the risk for future cardiovascular
events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within …