Inactivation of biologically active DNA by isopropanol and formate radicals

…, HA Van der Stroom, H Loman - International Journal of …, 1983 - Taylor & Francis
If OH and H radicals, produced by absorption of ionizing radiation in aqueous solutions, are
scavenged with isopropanol or sodium formate, secondary radicals are formed which can …

DNA damage induced by reduced nitroimidazole drugs

A Zahoor, MVM Lafleur, RC Knight, H Loman… - Biochemical …, 1987 - Elsevier
Five nitroimidazole drugs were reduced electrolytically and by γ-radiolysis at fast (300 μmoles
or 100% per hr) and slow (3–9 μmoles or 1–3% per hr) reduction rates in the presence of …

Inactivation of biologically active DNA by hydrated electrons

FJ Nabben, JP Karman, H Loman - International Journal of …, 1982 - Taylor & Francis
From a comparison of the inactivation yields of gamma-irradiated ϕX174 DNA with and without
an electron scavenger, we conclude that hydrated electrons inactivate DNA. However the …

Reaction rate of OH radicals with ϕX174 DNA: influence of salt and scavenger

…, T Mayer, J Blok, JB Verberne, H Loman - International Journal of …, 1985 - Taylor & Francis
A derivation is given for the dependence of the rate constant of the reaction of OH radicals
with a spherical macromolecule on the rate by which such radicals are scavenged by the …

Radiation-induced strand breaks in ϕX174 replicative form DNA: An improved experimental and theoretical approach

…, JB Verberne, J Retel, H Loman - International Journal of …, 1985 - Taylor & Francis
To determine the yield of radiation-induced single-strand, double-strand and potential breaks
(breaks which are converted into actual breaks by alkali or heat treatment) oxygenated …

Fast protonation of adenosine and of its radical anion formed by hydrated electron attack; a nanosecond optical and dc-conductivity pulse radiolysis study

KJ Visscher, MP De Haas, H Loman… - … Journal of Radiation …, 1987 - Taylor & Francis
The study of the reaction of the hydrated electron with adenosine by optical and dc-conductivity
pulse radiolysis on nano- and microsecond timescales has been carried out in an …

Excess electrons in ice

JB Verberne, H Loman, JM Warman, MP de Haas… - Nature, 1978 - nature.com
CONSIDERABLE evidence has accumulated for a highly structrued, ice-like nature of the
aqueous medium in certain cellular systems, particularly in the vicinity of macromolecules such …

60 Co γ-rays induce predominantly C/G to G/C transversions in double-stranded M13 DNA

…, J Brouwer, P van de Putte, H Loman… - Nucleic acids …, 1988 - academic.oup.com
Upon irradiation with gamma rays of an oxygenated aqueoua solution of double-stranded
M13 DNA, a very specific mutation spectrum was found with respect to both the type and the …

Alkali-labile sites and post-irradiation effects in gamma-irradiated biologically active double-stranded DNA in aqueous solution

MVM Lafleur, J Woldhuis, H Loman - International Journal of …, 1979 - Taylor & Francis
Gamma-irradiation of double-stranded RF-DNA of bacteriophage ϕX174 in aqueous solution
in the presence of oxygen produces at least one type of alkalilabile site. It is lethal and …

The Radiation Chemistry of Thymine in Aqueous Solution: Some Reactions of the Thymine-electron Adduct

H Loman, M Ebert - International Journal of Radiation Biology and …, 1970 - Taylor & Francis
The electron and OH adducts of thymine formed on irradiation of thymine in aqueous solutions
containing O 2 react rapidly with the dissolved O 2 : k(TOH + O 2 ) = 1·5 × 10 9 M −1 sec −…