Chemoresistance to platinum‑based chemotherapy for ovarian cancer in the advanced stage
remains a formidable concern clinically. Increasing evidence has revealed that apoptosis …

The mechanism of denaturation of proteins by urea is explored by using all-atom
microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L. …

The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie
restriction. We identified mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2…

The role of water in promoting the formation of protofilaments (the basic building blocks of
amyloid fibrils) is investigated using fully atomic molecular dynamics simulations. Our model …

We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440
(36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its …

Effect of aluminum fluoride complexation on fluoride removal by Al salts coagulation was
investigated by a series of batch experiments. Transformation of fluoride species in coagulation …

Hollow microstructure always exhibits some special properties in the field of electrochemistry.
Here, this study reports the rational design and preparation of TiNb 2 O 7 nanofibers with …

In this study, five aluminas were synthesized at different pH and calcination temperatures,
and the surface properties and defluoridation performance of aluminas were investigated. …

Ovarian cancer is one of the most common gynecological malignancies with highest mortality
rate among all gynecological malignant tumors. Advanced ovarian cancer patients can …

This paper aims to clarify global and local force harmonics and their effects on vibration in
permanent magnet (PM) synchronous machines. The local force includes both the tangential …