Mice carrying mutations in multiple genes are traditionally generated by sequential
recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single …

The type II bacterial CRISPR/Cas system is a novel genome-engineering technology with the
ease of multiplexed gene targeting. Here, we created reporter and conditional mutant mice …

Competitive coevolution between microbes and viruses has led to the diversification of
CRISPR–Cas defense systems against infectious agents. By analyzing metagenomic terabase …

IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading
to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-…

Good safety, high interfacial compatibility, low cost, and facile processability make polymer‐based
solid electrolytes promising materials for next‐generation batteries. Key issues related …

Although the biological effects of some nanomaterials have already been assessed, information
on toxicity and possible mechanisms of various particle types are insufficient. Moreover, …

Genome editing holds promise for correcting pathogenic mutations. However, it is difficult to
determine off-target effects of editing due to single-nucleotide polymorphism in individuals. …

Humans rely increasingly on sensors to address grand challenges and to improve quality of
life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are …

Global environmental change is rapidly altering the dynamics of terrestrial vegetation, with
consequences for the functioning of the Earth system and provision of ecosystem services 1 , …

Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding
to microbial or self DNA in the cytoplasm 1 . Upon binding DNA, cGAS produces cGAMP that …