Systematic mapping of protein–protein interactions, or ‘interactome’ mapping, was initiated
in model organisms, starting with defined biological processes 1 , 2 and then expanding to …

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

In apparently scale-free protein–protein interaction networks, or ‘interactome’ networks 1 , 2
, most proteins interact with few partners, whereas a small but significant proportion of …

Current yeast interactome network maps contain several hundred molecular complexes with
limited and somewhat controversial representation of direct binary interactions. We carried …

Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships. Here…

The recently completed Caenorhabditis elegans genome sequence allows application of
high-throughput (HT) approaches for phenotypic analyses using RNA interference (RNAi). As …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

Several attempts have been made to systematically map protein-protein interaction, or 'interactome',
networks. However, it remains difficult to assess the quality and coverage of existing …

Many human inherited neurodegenerative disorders are characterized by loss of balance
due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations …

Plants have unique features that evolved in response to their environments and ecosystems.
A full account of the complex cellular networks that underlie plant-specific functions is still …