Background Systemic effects of COPD are incompletely reflected by established prognostic
assessments. We determined the prognostic value of objectively measured physical activity …

Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving
neutrophilia features as a disrupted inflammatory process in the airways of patients with …

Rationale: Physical activity is reduced in patients with chronic obstructive pulmonary disease
(COPD). COPD has a systemic component that includes significant extrapulmonary effects …

The main complaint of patients with chronic obstructive pulmonary disease (COPD) is
shortness of breath with exercise, that is usually progressive. The principal mechanism that …

Background Conventional measures to evaluate COPD may fail to capture systemic problems,
particularly musculoskeletal weakness and cardiovascular disease. Identifying these …

This European Respiratory Society (ERS) statement provides a comprehensive overview on
physical activity in patients with chronic obstructive pulmonary disease (COPD). A …

Background Treatment with inhaled glucocorticoids in combination with long-acting
bronchodilators is recommended in patients with frequent exacerbations of severe chronic …

Background Little is known about the role of abnormal lung function in heart size and heart
dysfunction in patients with COPD. We studied the relationship of lung function with heart size …

Background The metabolic syndrome is a condition frequently found among individuals >
60 years of age. It predisposes affected individuals to systemic inflammation and physical …

Background Blood eosinophil counts might predict response to inhaled corticosteroids (ICS)
in patients with chronic obstructive pulmonary disease (COPD) and a history of …