Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should be …

At the recent Tuberous Sclerosis Consensus Conference, a subcommittee proposed
recommendations to guide the rational use of diagnostic studies in patients with tuberous sclerosis …

TSC and NF1 are the most common of the neurocutaneous diseases, and both are
autosomal dominant with a high spontaneous mutation rate. For diagnosis, two features are …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder of unknown aetiology
that affects numerous body systems including skin, brain and kidneys. Some TSC has been …

The analysis of big data is deemed to define a new era in urban research, planning and
policy. Real-time data mining and pattern detection in high-frequency data can now be carried …

Vaccines to protect against tuberculosis (TB) are urgently needed. We performed a case–control
analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin (…

ATP-binding cassette (ABC) transporters are integral membrane proteins that actively
transport molecules across cell membranes. In Escherichia coli they consist primarily of import …

We have reparameterized the dihedral parameters in a commonly used united-atom lipid
force field so that they can be used with the all-atom OPLS force field for proteins implemented …

Sie wollen vor allem keine chronologifch genaue Schilderung meiner Reifen fein:„An diefem
Tage marfchierten wir fiinf parafangen.“Manche Abfchnitte. die fich über wochen er| reckten…

At the beginning of each membrane protein simulation stands the generation of a suitable
starting structure which includes the two working steps of aligning the protein with the bilayer …