User profiles for Ian Toma

Ian Toma

Associate Research Professor, George Washington University
Verified email at gwu.edu
Cited by 1050

Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects

I Toma, TA McCaffrey - Cell and tissue research, 2012 - Springer
Age-related progression of cardiovascular disease is by far the largest health problem in the
US and involves vascular damage, progressive vascular fibrosis and the accumulation of …

Metataxonomic and metagenomic approaches vs. culture-based techniques for clinical pathology

…, E Castro-Nallar, M Pérez-Losada, I Toma… - Frontiers in …, 2016 - frontiersin.org
Diagnoses that are both timely and accurate are critically important for patients with life-threatening
or drug resistant infections. Technological improvements in High-Throughput …

Single-molecule long-read 16S sequencing to characterize the lung microbiome from mechanically ventilated patients with suspected pneumonia

I Toma, MO Siegel, J Keiser, A Yakovleva… - Journal of clinical …, 2014 - journals.asm.org
In critically ill patients, the development of pneumonia results in significant morbidity and
mortality and additional health care costs. The accurate and rapid identification of the microbial …

RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections

…, I Benjenk, E Heinz, OO Irondi, K Farrar, I Toma… - PloS one, 2022 - journals.plos.org
Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate
disease, up to critically severe. Severe disease, termed COVID-19, involves acute respiratory …

Clinical PathoScope: rapid alignment and filtration for accurate pathogen identification in clinical samples using unassembled sequencing data

…, S Manimaran, E Castro-Nallar, I Toma… - BMC …, 2014 - Springer
Background The use of sequencing technologies to investigate the microbiome of a sample
can positively impact patient healthcare by providing therapeutic targets for personalized …

Deep sequencing transcriptome analysis of murine wound healing: effects of a multicomponent, multitarget natural product therapy-Tr14

…, J Zhou, D Shtokalo, Y Vyatkin, M Ri, I Toma… - Frontiers in Molecular …, 2017 - frontiersin.org
Wound healing involves an orchestrated response that engages multiple processes, such as
hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation…

RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance

TA McCaffrey, I Toma, Z Yang, R Katz, J Reiner… - BMC Medical …, 2021 - Springer
Background Cardiovascular disease had a global prevalence of 523 million cases and 18.6
million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) …

Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells

S Zhaorigetu, Z Yang, I Toma, TA McCaffrey… - Journal of Biological …, 2011 - jbc.org
Inflammatory cytokine-regulated apoptosis and autophagy play pivotal roles in plaque
rupture and thrombosis of atherosclerotic lesions. However, the molecular interplay between …

How bioinformatics and open data can boost basic science in countries and universities with limited resources

…, B Langmead, JE Sanchez-Galan, I Toma… - Nature …, 2019 - nature.com
Providing training and access to standard computing hardware and cloud-based resources
can enable scientists in lower-resource institutions and countries to reanalyze published ' …

Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome

…, G St. Laurent III, N Hammell, I Toma… - … , and vascular biology, 2009 - ahajournals.org
Objective— Increasing evidence suggests that chronic inflammation contributes to atherogenesis,
and that acute inflammatory events cause plaque rupture, thrombosis, and myocardial …