The Tox21 10K compound library: collaborative chemistry advancing toxicology

…, P Shinn, BJ Collins, I Thillainadarajah… - Chemical Research …, 2020 - ACS Publications
Since 2009, the Tox21 project has screened ∼8500 chemicals in more than 70 high-throughput
assays, generating upward of 100 million data points, with all data publicly available …

ToxCast chemical landscape: paving the road to 21st century toxicology

…, CM Grulke, P Volarath, I Thillainadarajah… - Chemical research in …, 2016 - ACS Publications
The US Environmental Protection Agency’s (EPA) ToxCast program is testing a large library
of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to …

Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat

…, CR Blystone, I Thillainadarajah… - Toxicological …, 2007 - academic.oup.com
Triazole fungicides associated with a range of reported male reproductive effects in experimental
animals were selected to assess potential toxic modes of action. Wistar Han rats were …

[HTML][HTML] Assembly and curation of lists of per-and polyfluoroalkyl substances (PFAS) to support environmental science research

…, GFB Sinclair, V Samano, I Thillainadarajah… - Frontiers in …, 2022 - frontiersin.org
Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global
concern for many health and regulatory agencies due to their widespread use and persistence …

Effect of conazole fungicides on reproductive development in the female rat

…, MG Narotsky, KE Thompson, I Thillainadarajah… - Reproductive …, 2006 - Elsevier
Three triazole fungicides were evaluated for effects on female rat reproductive development.
Rats were exposed via feed to propiconazole (P) (100, 500, or 2500ppm), myclobutanil (M) (…

Inhibition of rat and human steroidogenesis by triazole antifungals

…, JC Rockett, H Ren, I Thillainadarajah… - Systems biology in …, 2009 - Taylor & Francis
Environmental chemicals that alter steroid production could interfere with male reproductive
development and function. Three agricultural antifungal triazoles that are known to modulate …

Comprehensive assessment of a chlorinated drinking water concentrate in a rat multigenerational reproductive toxicity study

…, JD Suarez, AS Murr, I Thillainadarajah… - … science & technology, 2013 - ACS Publications
Some epidemiological studies report associations between drinking water disinfection
byproducts (DBPs) and adverse reproductive/developmental effects, eg, low birth weight, …

Atrial natriuretic factor in experimental cirrhosis in rats

TR Morgan, K Morgan, GM Jonas, I Thillainadarajah - Gastroenterology, 1992 - Elsevier
Atrial natriuretic factor (ANF) is a cardiac hormone with potent natriuretic, diuretic, and
vasorelaxant properties. Although abnormalities in ANF release, plasma level, and renal receptors …

Wikipedia on the comptox chemicals dashboard: connecting resources to enrich public chemical data

G Sinclair, I Thillainadarajah, B Meyer… - Journal of Chemical …, 2022 - ACS Publications
The online encyclopedia Wikipedia aggregates a large amount of data on chemistry,
encompassing well over 20,000 individual Wikipedia pages and serves the general public as well …

Atrial natriuretic peptide in portal vein-Ligated rats: Alterations in cardiac production, plasma level and glomerular receptor density and affinity

GM Jonas, TR Morgan, K Morgan, I Thillainadarajah… - Hepatology, 1992 - journals.lww.com
The atrial natriuretic peptide hormonal system is altered to a variable degree in patients with
cirrhosis. Portal pressure and portal–systemic shunting are also varied in cirrhosis. We used …