We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce
periostin expression. We and others have subsequently shown that periostin is highly …

Periostin is a matricellular protein as well as an extracellular matrix (ECM) protein belonging
to the fasciclin family. Periostin plays important roles as a matricellular protein in the setting …

… Yamaura and Ono collected 260 cases of non-traumatic intracranial dissection, including
162 cases from the literature, 44 cases in their own series and additional 54 unpublished cases…

Background and Purpose— About one half of those who develop adult-onset moyamoya
disease experience intracranial hemorrhage. Despite the extremely high frequency of …

Photoradiation therapy (PRT) was performed in 13 lung cancer cases and in one case of
severely atypical squamous metaplasia following administration of hematoporphyrin derivative (…

Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of
chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The …

Suberin is a protective hydrophobic barrier consisting of phenolics, glycerol, and a variety of
fatty acid derivatives, including C18:0-C22:0 primary fatty alcohols. An eight-member gene …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …

… lungs of a–c) a 69-yr-old female nonsmoker, d–f) a 64-yr-old male with usual interstitial
pneumonia (UIP), g–i) a 62-yr-old female with fibrotic nonspecific interstitial pneumonia (fNSIP), j–…

Background Disease heterogeneity in patients with severe asthma and its relationship to
inflammatory mechanisms remain poorly understood. Objective We aimed to identify and …