A major challenge of biology is understanding the relationship between molecular genetic
variation and variation in quantitative traits, including fitness. This relationship determines our …

A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and summarize …

Determining the genetic architecture of complex traits is challenging because phenotypic
variation arises from interactions between multiple, environmentally sensitive alleles. We …

The microbiome shapes many host traits, yet the biology of microbiomes challenges traditional
evolutionary models. Here, we illustrate how integrating the microbiome into quantitative …

Epistasis—nonlinear genetic interactions between polymorphic loci—is the genetic basis of
canalization and speciation, and epistatic interactions can be used to infer genetic networks …

The importance of epistasis—non-additive interactions between alleles—in shaping
population fitness has long been a controversial topic, hampered in part by lack of empirical …

Predicting organismal phenotypes from genotype data is important for plant and animal
breeding, medicine, and evolutionary biology. Genomic-based phenotype prediction has been …

Quantitative genetics has primarily focused on describing genetic effects on trait means and
largely ignored the effect of alternative alleles on trait variability, potentially missing an …

Natural history collections are unparalleled repositories of geographical and temporal
variation in faunal conditions. Molecular studies offer an opportunity to uncover much of this …

In recent years, the advent of high-throughput assays, coupled with their diminishing cost,
has facilitated a systems approach to biology. As a consequence, massive amounts of data …