The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …

The development of fluorophores and molecular probes for the second near-infrared biological
window (NIR-II, 1000–1700 nm) represents an important, newly emerging and dynamic …

A remarkable feature of modern silicon electronics is its ability to remain physically invariant,
almost indefinitely for practical purposes. Although this characteristic is a hallmark of …

Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may
fail, at least in part, because the genomic alterations driving the growth of recurrences are …

Mamba is an effective state space model with linear computation complexity. It has recently
shown impressive efficiency in dealing with high-resolution inputs across various vision tasks…

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes.
Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor …

Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition
of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that …

To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional
Chinese medicine (TCM) prescribe a combination of plant species/minerals, called formulae, …

Although microRNAs (miRNAs) are key regulators of gene expression in normal human
physiology and disease, transcriptional regulation of miRNAs is poorly understood, because …

Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic
steatosis) contribute to approximately 2.5 million deaths annually 1 and are among the most …