HDL has been considered to be a protective factor in sepsis; however, most contributing studies
were conducted using the endotoxic animal model, and evidence from clinically relevant …

Within germinal centers (GCs), complex and highly orchestrated molecular programs must
balance proliferation, somatic hypermutation and selection to both provide effective humoral …

BACKGROUND In human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy
predicts progression to end-stage renal disease (ESRD). However, only about half of …

Vimentin has been implicated in pulmonary sarcoidosis as a T-cell autoantigen, particularly
in the context of HLA-DRB1*03, the Vα2.3/Vβ22 T-cell receptor (TCR), and Löfgren’s …

The T cell repertoire of healthy mice and humans harbors self-reactive CD4 + conventional
T (T conv ) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with …

Objective— Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor.
Recent studies revealed that SR-BI protects against sepsis via modulating innate immunity. …

In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with
both cell cycle exit and Igk recombination. Yet how the pre-BCR mediates these functions …

SR-BI regulates immunity via multiple mechanisms and its deficiency causes numerous
diseases. A comprehensive understanding of the roles of SR-BI in protection against immune …

Recent studies revealed that scavenger receptor BI (SR-BI or Scarb1) plays a critical
protective role in sepsis. However, the mechanisms underlying this protection remain largely …

Two-photon excitation microscopy (TPEM) has revolutionized the understanding of adaptive
immunity. However, TPEM usually requires animal models and is not amenable to the study …