RNAP II is frequently paused near gene promoters in mammals, and its transition to productive
elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II …

… 3 , Ji Xiong …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions of …

Background Schistosoma japonicum causes an infection involving humans, livestock, and
snails and is a significant cause of morbidity in China. Methods We evaluated a …

Intraoperative histology is essential for surgical guidance and decision-making. However,
frozen-sectioned hematoxylin and eosin (H&E) staining suffers from degraded accuracy, …

In this study, we describe the 3D chromosome regulatory landscape of human naive and
primed embryonic stem cells. To devise this map, we identified transcriptional enhancers and …

Recent transcriptome analysis indicates that > 90% of human genes undergo alternative
splicing, underscoring the contribution of differential RNA processing to diverse proteomes in …

Transcription factors (TFs) bind specific sequences in promoter-proximal and -distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA elements, …

Alternative splicing modulates expression of most human genes. The kinetic model of
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …

Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless
compartments to ensure that a wide variety of cellular activities occur in a spatially and …