User profiles for Jianfeng Xu
Jianfeng XuNorthShore University HealthSystem Verified email at NorthShore.org Cited by 69541 |
REVEL: an ensemble method for predicting the pathogenicity of rare missense variants
The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …
variants to complex traits is hampered by low statistical power and limited functional data. …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Inflammation in prostate carcinogenesis
About 20% of all human cancers are caused by chronic infection or chronic inflammatory
states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes …
states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes …
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
Chronic low-grade adipose tissue and liver inflammation is a major cause of systemic insulin
resistance and is a key component of the low degree of insulin sensitivity that exists in …
resistance and is a key component of the low degree of insulin sensitivity that exists in …
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
…, KR Benediktsdottir, M Jakobsdottir, J Xu… - Nature …, 2007 - nature.com
Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions
1 , with African American men having among the highest worldwide incidence and mortality …
1 , with African American men having among the highest worldwide incidence and mortality …
Genetic susceptibility to asthma—bronchial hyperresponsiveness coinherited with a major gene for atopy
…, PJ Amelung, KJ Holroyd, J Xu… - … England Journal of …, 1995 - Mass Medical Soc
Background Bronchial hyperresponsiveness, a risk factor for asthma, consists of a
heightened bronchoconstrictor response to a variety of stimuli. The condition has a heritable …
heightened bronchoconstrictor response to a variety of stimuli. The condition has a heritable …
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
JR Smith, D Freije, JD Carpten, H Grönberg, J Xu… - Science, 1996 - science.org
Despite its high prevalence, very little is known regarding genetic predisposition to prostate
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has …
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has …
Germline Mutations in HOXB13 and Prostate-Cancer Risk
Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …
molecular basis for this association is poorly understood. Linkage studies have implicated …
Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic …
Importance Data are limited regarding the association between CYP2C19 genetic variants
and clinical outcomes of patients with minor stroke or transient ischemic attack treated with …
and clinical outcomes of patients with minor stroke or transient ischemic attack treated with …
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Many studies have shown that primary prostate cancers are multifocal 1 , 2 , 3 and are
composed of multiple genetically distinct cancer cell clones 4 , 5 , 6 . Whether or not multiclonal …
composed of multiple genetically distinct cancer cell clones 4 , 5 , 6 . Whether or not multiclonal …