Over the last 25 years, biology has entered the genomic era and is becoming a science of ‘big
data’. Most interpretations of genomic analyses rely on accurate functional annotations of …

The pyridoxal 5′‐phosphate (PLP) homeostasis protein (PLPHP) is a ubiquitous member of
the COG0325 family with apparently no catalytic activity. Although the actual cellular role of …

Pyridoxal 5′-phosphate (PLP) is the active form of vitamin B 6 and a cofactor for many
essential metabolic processes such as amino acid biosynthesis and one carbon metabolism. 4’-…

By integrating a literature review with transcriptomic, proteomic, and phenotypic data from
two model bacteria, Escherichia coli and Vibrio cholerae, we put forward the hypothesis that …

Pyridoxal 5’-phosphate or PLP is a cofactor derived from B 6 vitamers and essential for growth
in all known organisms. PLP synthesis and salvage pathways are well characterized in a …

Inositol pyrophosphates are key effectors of eukaryal cellular phosphate homeostasis. They
are synthesized by kinases that add a β-phosphate to the 5- or 1-phosphate groups of IP 6 …

The pyridoxal 5′‐phosphate binding protein (PLP‐BP) is believed to play a crucial role in
PLP homeostasis, which may explain why it is found in living organisms from all kingdoms. …

tRNAs are the central adaptor molecule in translation and require a wide variety of post-transcriptional
modifications to fulfill their functions. The model gram-negative Escherichia coli K-…

Capturing the published corpus of information on all members of a given protein family
should be an essential step in any study focusing on specific members of that family. Using a …

We report that the small Escherichia coli membrane protein DrpB (formerly YedR) is involved
in cell division. We discovered DrpB in a screen for multicopy suppressors of a ΔftsEX …