Fluid protein biomarkers are important tools in clinical research and health care to support
diagnosis and to monitor patients. Especially within the field of dementia, novel biomarkers …

Cerebrospinal fluid (CSF) is an essential matrix for the discovery of neurological disease
biomarkers. However, the high dynamic range of protein concentrations in CSF hinders the …

The ubiquitous availability of genome sequencing data explains the popularity of machine
learning-based methods for the prediction of protein properties from their amino acid …

Proteomics studies have shown differential expression of numerous proteins in dementias
but have rarely led to novel biomarker tests for clinical use. The Marie Curie MIRIADE project …

Extracellular vesicles (EVs) are membranous structures released by cells into the extracellular
space and are thought to be involved in cell‐to‐cell communication. While EVs and their …

Motivation Antibodies play an important role in clinical research and biotechnology, with their
specificity determined by the interaction with the antigen’s epitope region, as a special type …

Repertoire sequencing allows us to investigate the antibody-mediated immune response.
The clustering of sequences is a crucial step in the data analysis pipeline, aiding in the …

Antibodies are indispensable in laboratory and clinical applications due to their high
specificity and affinity for protein antigens. However, selecting the right protein fragments as …

Frontotemporal dementia is a neurodegenerative disorder with high heterogeneity on the
genetic, pathological and clinical level. The familial form of the disease is mainly caused by …

Neurodegenerative dementias are progressive diseases that cause neuronal network
breakdown in different brain regions often because of accumulation of misfolded proteins in the …