User profiles for Keiji Tanaka
Keiji Tanaka東京都医学総合研究所 Verified email at igakuken.or.jp Cited by 131486 |
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Protein quality-control, especially the removal of proteins with aberrant structures, has an
important role in maintaining the homeostasis of non-dividing neural cells 1 . In addition to the …
important role in maintaining the homeostasis of non-dividing neural cells 1 . In addition to the …
Inferotemporal cortex and object vision
K Tanaka - Annual review of neuroscience, 1996 - annualreviews.org
Cells in area TE of the inferotemporal cortex of the monkey brain selectively respond to various
moderately complex object features, and those that cluster in a columnar region that runs …
moderately complex object features, and those that cluster in a columnar region that runs …
Neuronal mechanisms of object recognition
K Tanaka - Science, 1993 - science.org
Recognition of objects from their visual images is a key function of the primate brain. This
recognition is not a template matching between the input image and stored images like the …
recognition is not a template matching between the input image and stored images like the …
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
Autosomal recessive juvenile parkinsonism (AR–JP), one of the most common familial forms
of Parkinson disease, is characterized by selective dopaminergic neural cell death and the …
of Parkinson disease, is characterized by selective dopaminergic neural cell death and the …
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
…, T Ueno, E Kominami, H Motohashi, K Tanaka… - Nature cell …, 2010 - nature.com
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …
[HTML][HTML] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …
Ubiquitin is phosphorylated by PINK1 to activate parkin
PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been
identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism …
identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism …
Autophagy-deficient mice develop multiple liver tumors
Autophagy is a major pathway for degradation of cytoplasmic proteins and organelles, and
has been implicated in tumor suppression. Here, we report that mice with systemic mosaic …
has been implicated in tumor suppression. Here, we report that mice with systemic mosaic …
Molecular mechanisms of proteasome assembly
The 26S proteasome is a highly conserved protein degradation machine that consists of the
20S proteasome and 19S regulatory particles, which include 14 and 19 different …
20S proteasome and 19S regulatory particles, which include 14 and 19 different …
Analysis of motion of the visual field by direction, expansion/contraction, and rotation cells clustered in the dorsal part of the medial superior temporal area of the …
K Tanaka, HA Saito - Journal of neurophysiology, 1989 - journals.physiology.org
1. The dorsal part of the medial superior temporal area (MST) is characterized by clusters of
three types of visually responsive cells: Direction cells, which respond to a straight …
three types of visually responsive cells: Direction cells, which respond to a straight …