LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity

C Lacouture, B Chaves, D Guipouy, R Houmadi… - Nature …, 2024 - nature.com
LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. Here, we
show that LFA-1 … Super-resolution microscopy analysis reveals that >1000 LFA-1 nanoclusters …

The pharmacology of blinatumomab: state of the art on pharmacodynamics, pharmacokinetics, adverse drug reactions and evaluation in clinical trials

P Mocquot, Y Mossazadeh, L Lapierre… - Journal of Clinical …, 2022 - Wiley Online Library
… as CD69 and CD25 and adhesion molecules CD2 and LFA-1 (lymphocyte function-associated …
72 hours after administration and LFA-1 has a level that increases up to 6 days. LFA-1 is …

Effector memory–expressing CD45RA (TEMRA) CD8+ T cells from kidney transplant recipients exhibit enhanced purinergic P2X4 receptor–dependent …

TMD Ngoc, G Tilly, R Danger, O Bonizec… - Journal of the …, 2022 - journals.lww.com
… , and CXCL8, 5 , 7 and by the generation of functional ligands by memory CD8 T cells upon
post-translational modifications, such as the transition of the inactive to active state of LFA-1 …

Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome

A Magnani, M Semeraro, F Adam, C Booth, L Dupré… - Nature Medicine, 2022 - nature.com
… staining for F-actin, WASp and high-affinity LFA-1. The T cells from P5 were collected 55 …
c, Integrated fluorescence density for high-affinity LFA-1 in the same cells as in b. Overall, 28…

Postoperative ileus: a pharmacological perspective

E Buscail, C Deraison - British Journal of Pharmacology, 2022 - Wiley Online Library
Postoperative ileus (POI) is a frequent complication after abdominal surgery. The consequences
of postoperative ileus can be potentially serious such as bronchial inhalation or acute …

Nutritional status at age 1 year in patients born with esophageal atresia: a population-based, prospective cohort study

S Depoortere, A Lapillonne, R Sfeir, A Bonnard… - Frontiers in …, 2022 - frontiersin.org
… -age (LFA) ratio Z score at ages 6 months and 1 year using the most recent French reference
growth … more representative of growth among contemporary French children (17). BMI and …

Plant–microbe interactions that have impacted plant terrestrializations

C Puginier, J Keller, PM Delaux - Plant Physiology, 2022 - academic.oup.com
… Although the range of terrestrial habitats increases through lichenization for LFA, it was
shown that the LFA themselves have their own desiccation tolerance toolkit that adds up to the …

Genome mosaicism in field strains of Mycoplasma bovis as footprints of in-host horizontal chromosomal transfer

A García-Galán, E Baranowski… - Applied and …, 2022 - Am Soc Microbiol
… Bioinformatic analyses were conducted on the Galaxy platform (Genotoul, Toulouse,
France). The quality of the sequencing reads was analyzed with the FastQC tool (https://www.…

Pulse Width Modulation current control for LED lighting horticulture systems

L Bachouch, N Sewraj, P Dupuis… - 2022 IEEE Industry …, 2022 - ieeexplore.ieee.org
This paper presents a DC-DC LED driver for a 200 W luminaire dedicated to greenhouses
lighting applications. Plants are more sensitive to particular radiations for their growth. Hence, …

Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cells

L Filali, MP Puissegur, K Cortacero, S Cussat-Blanc… - Science …, 2022 - science.org
… were stored at the CRB Cancer des Hôpitaux de Toulouse collection. In accordance with
French law, the CRB cancer collection has been declared to the Ministry of Higher Education …