Calorie restriction extends lifespan and produces a metabolic profile desirable for treating
diseases of ageing such as type 2 diabetes 1 , 2 . SIRT1, an NAD + -dependent deacetylase, …

Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation
proteases until it binds to the heparan side chains that line the microvasculature. The binding …

Construction of a complex virus may involve a hierarchy of assembly elements. Here, we
report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo–…

In this article, we characterize the fluorescence of an environmentally sensitive probe for
lipid membranes, di-4-ANEPPDHQ. In large unilamellar lipid vesicles (LUVs), its emission …

Owing to the exceptional properties of graphene, intensive studies have been carried out on
novel two-dimensional (2D) materials. In the past several years, an elegant exfoliation …

Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis
in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

BACKGROUND & AIMS: Recent studies have suggested that CD4 + CD25 + regulatory T
cells (Treg) are increased and linked to compromised immune responses in patients with …

EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …

Recently, automatic visual data understanding from drone platforms becomes highly demanding.
To facilitate the study, the Vision Meets Drone Object Detection in Image Challenge is …

The tumor suppressor p53 is activated in response to cellular stress to prevent malignant
transformation by activation of the DNA repair machinery to preserve the cell, or by induction of …