Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) amplification or
overexpression occurs in approximately 20% of advanced gastric or gastro-oesophageal …

Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic
indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. …

Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of
high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL …

Purpose To assess the toxicity, pharmacokinetics, and pharmacodynamics of multikinase
inhibitor sorafenib in combination with clofarabine and cytarabine in children with relapsed/…

The study of brain age has emerged over the past decade, aiming to estimate a person’s
age based on brain imaging scans. Ideally, predicted brain age should match chronological …

Purpose: Many tyrosine kinase inhibitors (TKI) undergo extensive hepatic metabolism, but
mechanisms of their hepatocellular uptake remain poorly understood. We hypothesized that …

A high-performance liquid chromatographic method was applied to the determination of
danshensu, protocatechuic aldehyde, rosmarinic acid, lithospermic acid, salvianolic acid B and …

Pembrolizumab plus trastuzumab and chemotherapy for HER2+ metastatic gastric or
gastroesophageal junction (G/GEJ) cancer: Initial findings of the global phase 3 KEYNOTE-811 …

Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause
early right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves …

Membrane transporters are key determinants of therapeutic outcomes. They regulate systemic
and cellular drug levels influencing efficacy as well as toxicities. Here we report a unique …