Background Patients with peripheral artery disease who have undergone lower-extremity
revascularization are at high risk for major adverse limb and cardiovascular events. The …

Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice,
is gaining more and more attention and application worldwide. And TCM-based new drug …

Background Critical limb ischemia (CLI) represents the most severe clinical manifestation of
peripheral arterial disease (PAD) and is the major cause of ischemic amputation in the …

There are multiple mechanisms by which adenine nucleotides can be released into the
extracellular space in brain. Adenine nucleotides are converted extracellularly to adenosine, …

Traditional Chinese medicine (TCM) is increasingly recognized and utilized worldwide.
However, the complex ingredients of TCM and their interactions with the human body make …

The ubiquitination mediated by ubiquitin activating enzyme (E1), ubiquitin conjugating
enzyme (E2), and ubiquitin ligase (E3) cascade is crucial to protein degradation, transcription …

Because adenosine is taken up rapidly and metabolized by brain tissue, it has been difficult
to establish its true pharmacological potency and, for similar reasons, to determine the basal …

As an important post-translational modification, ubiquitination mediates ∼80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …

The adenosine A 3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

To date, only some cancer patients can benefit from chemotherapy and targeted therapy.
Drug resistance continues to be a major and challenging problem facing current cancer …