This review covers a special topic in carbohydrate chemistry — solvent effects on the
stereoselectivity of glycosylation reactions. Obtaining highly stereoselective glycosidic linkages is …

Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-throughput
automated imaging has enabled the capturing of a wide range of morphological …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …

Directed self-assembly of small molecules in living systems could enable a myriad of
applications in biology and medicine, and already this has been used widely to synthesize …

Heparanase-1 (HPSE) is a promising yet challenging therapeutic target. It is the only known
enzyme that is responsible for cleavage of heparan sulfate (HS) side chains from heparan …

Phosphorylation modification is required for the modulation of phytochrome B (phyB) thermal
reversion, but the kinase(s) that phosphorylate(s) phyB and the biological significance of …

Deciphering universal gene regulatory mechanisms in diverse organisms holds great
potential for advancing our knowledge of fundamental life processes and facilitating clinical …

Background Despite emerging evidence on the therapeutic potential of mesenchymal stem
cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC-…

We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery
system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to …

Non-invasive detection of caspase-3/7 activity in vivo has provided invaluable predictive
information regarding tumor therapeutic efficacy and anti-tumor drug selection. Although a …