α-Tubulin acetylation at Lys-40, located on the luminal side of microtubules, has been widely
studied and used as a marker for stable microtubules in the cilia and other subcellular …

Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was
not until the past 5 years that its mutations in humans caught increasing attention. Those …

Histone deacetylases 4 (HDAC4), -5, -7, and -9 form class IIa within the HDAC superfamily
and regulate diverse physiological and pathological cellular programs. With conserved motifs …

Lysine acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino
group of a lysine residue on a protein. This has recently emerged as a major covalent …

Here we present ICARUS, a web server to enable users without experience in R to undertake
single cell RNA-seq analysis. The focal point of ICARUS is its intuitive tutorial-style user …

Epigenetic mechanisms are important in different neurological disorders, and one such
mechanism is histone acetylation. The multivalent chromatin regulator BRPF1 (bromodomain- …

Lysine acetylation has recently emerged as an important post-translational modification in
diverse organisms, but relatively little is known about its roles in mammalian development and …

Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by an expansion
in the CAG repeat tract of the huntingtin (HTT) gene resulting in behavioural, cognitive, and …

Hematopoietic stem cells (HSCs) serve as a life-long reservoir for all blood cell types and
are clinically useful for a variety of HSC transplantation-based therapies. Understanding the …

Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with uncertain genetic
predisposition in most sporadic cases. The spatial architecture of cell types and gene …