FKHR is a member of the FOXO subfamily of Forkhead transcription factors, which are
important targets for insulin and growth factor signaling. FKHR contains three predicted protein …

FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor
action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, …

Metabolic reprogramming greatly contributes to the regulation of macrophage activation.
However, the mechanism of lipid accumulation and the corresponding function in tumor-…

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from
simple steatosis to advanced pathologies, including nonalcoholic steatohepatitis and cirrhosis…

Overnutrition activates a proinflammatory program in macrophages to induce insulin resistance
(IR), but its molecular mechanisms remain incompletely understood. Here, we show that …

… cells that ectopic expression of OB-Rb markedly increased leptin signaling activity (Gan …
Lixia Gan designed experiments, wrote the manuscript and takes full responsibility for the …

As a medium that can convey information vividly, the application of digital images is
increasingly widespread. Under various application environments, researchers are expected to …

Increasing evidence suggests that inflammation/cytokines may modulate hypothalamic
responses to leptin, which is a key regulator of energy homeostasis and inflammatory/stress …

Ethanol induces hypoxia and elevates HIF-1α in the liver. CYP2E1 plays a role in the
mechanisms by which ethanol generates oxidative stress, fatty liver, and liver injury. This study …

Proinflammatory cytokines play a causal role in the development of hyperinsulinemia and
T2MD. FOXO1, a transcription factor which is known to enhance proinflammation, was recently …