User profiles for Lizhen Zheng

Li-Zhen Zheng

The Chinese University of Hong Kong
Verified email at ort.cuhk.edu.hk
Cited by 3741

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

…, S Chen, JQ Feng, DHK Chow, X Xie, L Zheng… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture repair
with considerable efficacy; however, the underlying mechanisms by which these implants …

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

G Zhang, B Guo, H Wu, T Tang, BT Zhang, L Zheng… - Nature medicine, 2012 - nature.com
Metabolic skeletal disorders associated with impaired bone formation are a major clinical
challenge. One approach to treat these defects is to silence bone-formation–inhibitory genes …

Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects

…, J Xu, K Zhang, H Yao, N Zheng, L Zheng… - ACS central …, 2019 - ACS Publications
Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for
biomedical applications. However, most conventional hydrogels cannot be injected after …

Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis

Y Li, J Xu, J Mi, X He, Q Pan, L Zheng, H Zu, Z Chen… - Biomaterials, 2021 - Elsevier
Critical size bone defects are frequently caused by accidental trauma, oncologic surgery,
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …

Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy

X Li, B Dai, J Guo, L Zheng, Q Guo, J Peng, J Xu… - Nano-micro letters, 2021 - Springer
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically used …

Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis

…, C Hopkins, H Wang, H Yao, J Mi, L Zheng… - Nature …, 2022 - nature.com
Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone …

Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: proof-of-concept for prevention of hip joint collapse in bipedal emus and …

L Qin, D Yao, L Zheng, WC Liu, Z Liu, M Lei, L Huang… - Biomaterials, 2015 - Elsevier
Steroid-associated osteonecrosis (SAON) may lead to joint collapse and subsequent joint
replacement. Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing …

[HTML][HTML] Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice

…, J Wang, Y Zhang, N Zheng, J Yue, J Mi, L Zheng… - Bioactive materials, 2021 - Elsevier
Introduction We previously demonstrated that magnesium ions (Mg 2+ ) was a novel therapeutic
alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-…

A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice

…, DHK Chow, L Tian, H Wu, J Zhang, N Wang, L Zheng… - Biomaterials, 2018 - Elsevier
Targeting delivery system has been widely used in packaging drugs for medical therapies
attributed to its high efficiency and efficacy. A Traditional Chinese Medicine (TCM) formula …

64-kb hybrid Josephson-CMOS 4 Kelvin RAM with 400 ps access time and 12 mW read power

T Van Duzer, L Zheng, SR Whiteley… - IEEE Transactions …, 2012 - ieeexplore.ieee.org
We have designed, simulated, fabricated, and tested a 64-kb hybrid Josephson-CMOS
memory using a 5 mm × 5 mm Josephson interface chip and a 2.0 × 1.5 mm CMOS chip. The …