Methylation-induced transcriptional silencing of the fragile X mental retardation-1 (Fmr1)
gene leads to absence of the gene product, fragile X mental retardation protein (FMRP), and …

Sulfur (S) fertilizer application in rice (Oryza sativa L.) is crucial in determining rice grain
productivity and quality. However, little information is available concerning the effect of S supply …

In healthy individuals, skin integrity is maintained by epidermal stem cells which self‐renew
and generate daughter cells that undergo terminal differentiation. It is currently unknown …

Background Recurrence and metastasis are the leading causes of tumour-related death in
patients with oesophageal squamous cell carcinoma (ESCC). Tumour-infiltrating natural killer …

A series of polyurethane/vinyl ester resin simultaneous and gradient interpenetrating polymer
networks (PU/VER IPN and gradient IPN), cured at room temperature, were synthesized by …

Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by
classical Michaelis-Menten kinetic parameters (eg, K m and V max ), which are usually …

Nonlinear model predictive control (NMPC) requires a repeated online solution of a nonlinear
optimal control problem. The computation load remains the main challenge for the real-…

In vitro studies were conducted to identify the cytochromes P450 (CYP) involved in the
oxidative metabolism of celecoxib. The hydroxylation of celecoxib conformed to monophasic …

Nicotine is thought to be the key substance responsible for tobacco-smoking habits and
appears to trigger reinforcement via the ventral tegmental area (VTA). Recently, multiple …

Cytochrome P450 3A4 (CYP3A4) plays a prominent role in the metabolism of a vast array of
drugs and xenobiotics and exhibits broad substrate specificities. Most cytochrome P450-…