User profiles for Robert J. Flassig

Robert J Flassig

Professor at University of Applied Sciences Brandenburg
Verified email at th-brandenburg.de
Cited by 601

Dynamic flux balance modeling to increase the production of high-value compounds in green microalgae

RJ Flassig, M Fachet, K Höffner, PI Barton… - Biotechnology for …, 2016 - Springer
Background Photosynthetic organisms can be used for renewable and sustainable
production of fuels and high-value compounds from natural resources. Costs for design and …

Reactor-network synthesis via flux profile analysis

NM Kaiser, RJ Flassig, K Sundmacher - Chemical Engineering Journal, 2018 - Elsevier
Within the framework of elementary process functions (Freund and Sundmacher, 2008) an
approach is developed to derive reactor-network candidates from the solution of a dynamic …

Quantitative single cell analysis uncovers the life/death decision in CD95 network

…, D Pischel, K Sundmacher, RJ Flassig… - PLoS computational …, 2018 - journals.plos.org
CD95/Fas/APO-1 is a member of the death receptor family that triggers apoptotic and anti-apoptotic
responses in particular, NF-κB. These responses are characterized by a strong …

Probabilistic reactor design in the framework of elementary process functions

NM Kaiser, RJ Flassig, K Sundmacher - Computers & Chemical …, 2016 - Elsevier
Computational process models in combination with innovative design methodologies
provide a powerful reactor design platform. Yet, model-based design is mostly done in a pure …

Knowledge based 2D blade design using multi-objective aerodynamic optimization and a neural network

…, PM Flassig, RJ Flassig… - … Expo: Power for …, 2007 - asmedigitalcollection.asme.org
This paper presents a method to obtain optimized 2D blade sections using expert knowledge,
a multi-criteria optimization approach and a neural network in an automated process. A …

Reconstruction and analysis of a carbon-core metabolic network for Dunaliella salina

M Fachet, C Witte, RJ Flassig, LK Rihko-Struckmann… - BMC …, 2020 - Springer
Background The green microalga Dunaliella salina accumulates a high proportion of β-carotene
during abiotic stress conditions. To better understand the intracellular flux distribution …

TRANSWESD: inferring cellular networks with transitive reduction

S Klamt, RJ Flassig, K Sundmacher - Bioinformatics, 2010 - academic.oup.com
Motivation: Distinguishing direct from indirect influences is a central issue in reverse
engineering of biological networks because it facilitates detection and removal of false positive …

Optimal design of stimulus experiments for robust discrimination of biochemical reaction networks

RJ Flassig, K Sundmacher - Bioinformatics, 2012 - academic.oup.com
Motivation: Biochemical reaction networks in the form of coupled ordinary differential equations
(ODEs) provide a powerful modeling tool for understanding the dynamics of biochemical …

A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data

…, JH Buchbinder, K Sundmacher, IN Lavrik, RJ Flassig - PLoS …, 2018 - journals.plos.org
Imaging flow cytometry is a powerful experimental technique combining the strength of
microscopy and flow cytometry to enable high-throughput characterization of cell populations on …

Energy and operating cost assessment of competing harvesting methods for D. salina in a β-carotene production process

K Pirwitz, RJ Flassig, LK Rihko-Struckmann… - Algal research, 2015 - Elsevier
A new evaluation concept to assess microalgal harvesting methods was introduced using β-carotene
production with Dunaliella salina as a case study. Detailed experiments were …