Influences of pulsed electric field parameters on cell electroporation and electrofusion events: Comprehensive understanding by experiments and molecular dynamics …
S Qu, Q Ke, X Li, L Yu, S Huang - PloS one, 2025 - journals.plos.org
Electroporation and electrofusion are efficient methods, which have been widely used in
different areas of biotechnology and medicine. Pulse strength and width, as an external …
different areas of biotechnology and medicine. Pulse strength and width, as an external …
Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol
T Liu, X Pan, L Chao, W Tan, S Qu, L Yang… - Journal of chemical …, 2014 - ACS Publications
Flexible peptides binding to human leukocyte antigen (HLA) play a key role in mediating
human immune responses and are also involved in idiosyncratic adverse drug reactions …
human immune responses and are also involved in idiosyncratic adverse drug reactions …
Constructing interconsistent, reasonable, and predictive models for both the kinetic and thermodynamic properties of HIV-1 protease inhibitors
S Qu, S Huang, X Pan, L Yang… - Journal of Chemical …, 2016 - ACS Publications
Accumulated evidence suggests that the in vivo biological potency of a ligand is more strongly
correlated with the binding/unbinding kinetics than the equilibrium thermodynamics of the …
correlated with the binding/unbinding kinetics than the equilibrium thermodynamics of the …
SMD-based interaction-energy fingerprints can predict accurately the dissociation rate constants of HIV-1 protease inhibitors
S Huang, D Zhang, H Mei, MY Kevin, S Qu… - Journal of chemical …, 2018 - ACS Publications
Recent research has increasingly suggested that the crucial factors affecting drug potencies
are related not only to the thermodynamic properties but also to the kinetic properties. …
are related not only to the thermodynamic properties but also to the kinetic properties. …
An improved large-scale prediction model of CYP1A2 inhibitors by using combined fragment descriptors
X Pan, L Chao, S Qu, S Huang, L Yang, H Mei - RSC Advances, 2015 - pubs.rsc.org
CYP1A2, an important member of the cytochromes P450 (CYPs) superfamily, is involved in
the metabolism or bioactivation of many clinical drugs and precarcinogens. Thus, accurate …
the metabolism or bioactivation of many clinical drugs and precarcinogens. Thus, accurate …
Prediction and characterization of P-glycoprotein substrates potentially bound to different sites by emerging chemical pattern and hierarchical cluster analysis
X Pan, H Mei, S Qu, S Huang, J Sun, L Yang… - International Journal of …, 2016 - Elsevier
P-glycoprotein (P-gp), an ATP-binding cassette (ABC) multidrug transporter, can actively
transport a broad spectrum of chemically diverse substrates out of cells and is heavily involved …
transport a broad spectrum of chemically diverse substrates out of cells and is heavily involved …
Allosteric effects of ATP binding on the nucleotide-binding domain of a heterodimeric ATP-binding cassette transporter
X Pan, Q Zhang, S Qu, S Huang, H Wang… - Integrative …, 2016 - academic.oup.com
ATP-binding cassette (ABC) exporters mediate vital transport of a variety of molecules
across the lipid bilayer in all organisms. To explore the allosteric effect of ATP binding at the …
across the lipid bilayer in all organisms. To explore the allosteric effect of ATP binding at the …
Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C.
…, DZP Duan ZhongPing, ZSJ Zheng SuJun - 2015 - cabidigitallibrary.org
AIM: To investigate the relationship between serum vitamin D 3 levels and liver fibrosis or
inflammation in treatment-naive Chinese patients with chronic hepatitis C (CHC). METHODS: …
inflammation in treatment-naive Chinese patients with chronic hepatitis C (CHC). METHODS: …
Serum sphingomyelin has potential to reflect hepatic injury in chronic hepatitis B virus infection.
ZSJ Zheng SuJun, QF Qu Feng, LJF Li JunFeng… - 2015 - cabidigitallibrary.org
Objective: To explore the relation between serum sphingolipids and hepatic injury in chronic
HBV infection. Methods: A cohort of participants including 48 healthy persons, 103 chronic …
HBV infection. Methods: A cohort of participants including 48 healthy persons, 103 chronic …
Lipidomic profiling of plasma in patients with chronic hepatitis C infection.
QF Qu Feng, ZSJ Zheng SuJun, WCS Wu CaiSheng… - 2014 - cabidigitallibrary.org
Chronic hepatitis C virus (HCV) infection is a global health issue. Although its progression is
reported to be closely associated with lipids, the way in which the plasma lipidome changes …
reported to be closely associated with lipids, the way in which the plasma lipidome changes …