Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

Protein aggregation and abnormal lipid homeostasis are both implicated in
neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane …

Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures
of aggregate populations that are closely linked to neurodegenerative conditions, such as …

Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely
linked to neuronal death in Parkinson’s disease. However, the heterogeneity of different co…

Protein aggregates play a key role in the initiation and spreading of neurodegenerative
disease but have been difficult to study due to their low abundance and heterogeneity, in both …

Soluble aggregates of the microtubule-associated protein tau have been challenging to
assemble and characterize, despite their important role in the development of tauopathies. We …

Proteins fold into a single structural ensemble but can also misfold into many diverse structures
including small aggregates and fibrils, which differ in their toxicity. The aggregate surface …

As a key player of the protein quality control network of the cell, the molecular chaperone
Hsp70 inhibits the aggregation of the amyloid protein tau. To date, the mechanism of this …

… Compte tenu de ces découvertes, nous proposons un autre modèle tectonique, soit la formation
de … Des exemples visibles de nos jours de ce milieu se retrouvent dans les ceintures de …

To quantify and characterize the potentially toxic protein aggregates associated with
neurodegenerative diseases, a high‐throughput assay based on measuring the extent of aggregate…