A new series of side-chain modified 4-aminoquinolines have been synthesized and found
active against P. falciparum in vitro and P. yoelli in vivo. Compounds 6, 11, 12, and 19 …

Licochalcone A (I), isolated from the roots of Chinese licorice, is the most promising antimalarial
compound reported so far. In continuation of our drug discovery program, we isolated …

Major blood stage antimalarial drugs like chloroquine and artemisinin target the heme
detoxification process of the malaria parasite. Hemozoin formation reactions in vitro using the …

A series of novel tetrazole derivatives of 4-aminoquinoline were synthesized and screened
for their antimalarial activities against both chloroquine-senstive (3D7) and chloroquine-…

Background Minimal hepatic encephalopathy ( MHE ) represents the mildest form of hepatic
encephalopathy ( HE ), with abnormal neuropsychologic findings. Inflammatory response …

A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in
vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as …

Choline kinase is the first enzyme in the Kennedy pathway (CDP-choline pathway) for the
biosynthesis of the most essential phospholipid, phosphatidylcholine, in Plasmodium …

Objectives The objective of this study was to identify a nitroimidazo-oxazole lead molecule
for the treatment of visceral leishmaniasis (VL). Methods A library of 72 nitroimidazo-oxazoles …

Red cell invasion by Plasmodium merozoites involves multiple steps such as attachment,
apical reorientation, junction formation and entry into a parasitophorous vacuole. These steps …

An analogous library of 2-substituted quinoline compounds was synthesized with the aim to
identify a potential drug candidate to treat visceral leishmaniasis. These molecules were …