Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry
Blood serum is a complex body fluid that contains various proteins ranging in concentration
over at least 9 orders of magnitude. Using a combination of mass spectrometry technologies …
over at least 9 orders of magnitude. Using a combination of mass spectrometry technologies …
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome
SM Varnum, DN Streblow, ME Monroe, P Smith… - Journal of …, 2004 - Am Soc Microbiol
Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex
enveloped virus composed of both viral and cellular gene products. While the sequence of the …
enveloped virus composed of both viral and cellular gene products. While the sequence of the …
Specific DNA binding of GAL4, a positive regulatory protein of yeast
E Giniger, SM Varnum, M Ptashne - Cell, 1985 - Elsevier
We show by the following series of experiments that the yeast positive regulatory protein
GAL4 binds to four sites in the upstream activating sequence UAS G to activate transcription of …
GAL4 binds to four sites in the upstream activating sequence UAS G to activate transcription of …
Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy
…, T Liu, X Zhang, HM Mottaz, SM Varnum… - Molecular & Cellular …, 2008 - ASBMB
The enormous dynamic range of human bodily fluid proteomes poses a significant challenge
for current MS-based proteomics technologies as it makes it especially difficult to detect low …
for current MS-based proteomics technologies as it makes it especially difficult to detect low …
Targeted Mutagenesis by Duplication Insertion in the Radioresistant Bacterium Deinococcus radiodurans: Radiation Sensitivities of Catalase (katA) and Superoxide Dismutase …
LM Markillie, SM Varnum, P Hradecky… - Journal of …, 1999 - Am Soc Microbiol
Deinococcus radiodurans R1 is extremely resistant to both oxidative stress and ionizing
radiation. A simple and general targeted mutagenesis method was developed to generate …
radiation. A simple and general targeted mutagenesis method was developed to generate …
[HTML][HTML] High dynamic range characterization of the trauma patient plasma proteome
Although human plasma represents an attractive sample for disease biomarker discovery,
the extreme complexity and large dynamic range in protein concentrations present significant …
the extreme complexity and large dynamic range in protein concentrations present significant …
The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus
PA Krieg, SM Varnum, WM Wormington… - Developmental …, 1989 - Elsevier
A Xenopus laevis gastrula cDNA library has been screened in order to identify sequences
that are expressed early in development. We find that the mRNA encoding translation …
that are expressed early in development. We find that the mRNA encoding translation …
Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer
SM Varnum, CC Covington, RL Woodbury… - Breast cancer research …, 2003 - Springer
Mammary ductal cells are the origin for 70–80% of breast cancers. Nipple aspirate fluid (NAF)
contains proteins directly secreted by the ductal and lobular epithelium in non-lactating …
contains proteins directly secreted by the ductal and lobular epithelium in non-lactating …
Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice
…, AR Murray, ER Kisin, SM Varnum… - Toxicological …, 2011 - academic.oup.com
Reflecting their exceptional potential to advance a range of biomedical, aeronautic, and
other industrial products, carbon nanotube (CNT) production and the potential for human …
other industrial products, carbon nanotube (CNT) production and the potential for human …
Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data
Liquid chromatography−mass spectrometry-based (LC−MS) proteomics uses peak intensities
of proteolytic peptides to infer the differential abundance of peptides/proteins. However, …
of proteolytic peptides to infer the differential abundance of peptides/proteins. However, …