Inflammation is increasingly regarded as a key process underlying metabolic diseases in
obese individuals. In particular, obese adipose tissue shows features characteristic of active …

Intravital visualization of thrombopoiesis revealed that formation of proplatelets, which are
cytoplasmic protrusions in bone marrow megakaryocytes (MKs), is dominant in the steady state…

The volume change behaviour of fine-grained soils under repeated freeze–thaw cycles was
investigated in context of artificial ground freezing, in which relatively quick freezing is …

OBJECTIVE—The expansion of adipose tissue mass seen in obesity involves both hyperplasia
and hypertrophy of adipocytes. However, little is known about how adipocytes, adipocyte …

Distinct B cell populations, designated regulatory B (B reg ) cells, are known to restrain
immune responses associated with autoimmune diseases. Additionally, obesity is known to …

To assess physiological and pathophysiological events that involve dynamic interplay between
multiple cell types, real-time, in vivo analysis is necessary. We developed a technique …

Metabolic syndrome is a major risk factor for cardiovascular and metabolic diseases. Playing
a central role in the development of metabolic syndrome and in its clinical consequences is …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Adipose tissue expression and circulating concentrations of monocyte chemoattractant
protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1 …

The mechanism by which thrombotic vessel occlusion occurs independently of plaque
development or endothelial cell (EC) disruption remains unclear, largely because of an inability to …