Intravenous immunoglobulin ameliorates ITP via activating Fcγ receptors on dendritic cells

V Siragam, AR Crow, D Brinc, S Song, J Freedman… - Nature medicine, 2006 - nature.com
Despite a more than 20-year experience of therapeutic benefit, the relevant molecular and
cellular targets of intravenous immunoglobulin (IVIg) in autoimmune disease remain unclear. …

A framework for the general design and computation of hybrid neural networks

…, Y Wu, F Liu, Z Wu, L Li, F Chen, S Song… - Nature …, 2022 - nature.com
There is a growing trend to design hybrid neural networks (HNNs) by combining spiking
neural networks and artificial neural networks to leverage the strengths of both. Here, we …

IVIg inhibits reticuloendothelial system function and ameliorates murine passive‐immune thrombocytopenia independent of anti‐idiotype reactivity

AR Crow, S Song, JW Semple… - British journal of …, 2001 - Wiley Online Library
Although the mechanism of action of intravenous immunoglobulin (IVIg) in treating antibody‐dependent
thrombocytopenia remains unclear, most studies have suggested that IVIg …

Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia

AR Crow, S Song, V Siragam… - Pediatric blood & …, 2006 - Wiley Online Library
Intravenous immunoglobulin (IVIG) is currently used to treat a multitude of autoimmune disorders
including immune thrombocytopenic purpura (ITP), yet the mechanism of action of IVIG …

IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activity

AR Crow, S Song, J Freedman, CD Helgason… - Blood, 2003 - ashpublications.org
It has been established that amelioration of murine immune thrombocytopenia purpura (ITP)
by IVIg is dependent on the inhibitory receptor FcγRIIB. Co-cross-linking of the FcγRIIB with …

Frequency analysis and clinical characterization of spinocerebellar ataxia types 1, 2, 3, 6, and 7 in Korean patients

WY Lee, DK Jin, MR Oh, JE Lee, SM Song… - Archives of …, 2003 - jamanetwork.com
Background By genetic analysis, the CAG repeat expansion has been established in
spinocerebellar ataxia (SCA) types 1, 2, 3, 6, and 7. Despite the genetic differentiation of SCA, the …

Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?

V Siragam, D Brinc, AR Crow, S Song… - The Journal of clinical …, 2005 - jci.org
Intravenous Ig (IVIg) mediates protection from the effects of immune thrombocytopenic purpura
(ITP) as well as numerous other autoimmune states; however, the active antibodies within …

Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG

S Song, AR Crow, J Freedman… - Blood, The Journal of …, 2003 - ashpublications.org
Intravenous immunoglobulin (IVIG) is used to treat immune thrombocytopenia resulting from
a variety of autoimmune and nonautoimmune diseases such as idiopathic …

Interleukin-10 inhibits interferon-γ–induced intercellular adhesion molecule-1 gene transcription in human monocytes

S Song, H Ling-Hu, KA Roebuck… - Blood, The Journal …, 1997 - ashpublications.org
Interleukin-10 (IL-10) is a potent monocyte regulatory cytokine that inhibits gene expression
of proinflammatory mediators. In this study, we investigated the mechanism by which IL-10 …

Identification of mutations in the GNPTA (MGC4170) gene coding for GlcNAc‐phosphotransferase α/β subunits in Korean patients with mucolipidosis type II or type IIIA

KH Paik, SM Song, CS Ki, HW Yu, JS Kim… - Human …, 2005 - Wiley Online Library
Mucolipidosis types II and III are autosomal recessive inherited diseases caused by a
deficiency in the lysosomal enzyme N‐acetylglucosamine‐1 phosphotransferase (GlcNAc‐…