Ca 2+ /calmodulin-dependent protein kinase II γ (CAMKIIγ) has been identified as a potential
target for treating cancer. Based on our previous study of berbamine (BBM) as a CAMKIIγ …

Germinal center (GC) responses potentiate the generation of follicular regulatory T (T FR )
cells. However, the molecular cues driving T FR cell formation remain unknown. Here, we …

The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. …

Background & Aims Alcohol-associated liver disease (AALD) is one of the most common
causes of liver injury and failure. Limited knowledge of the mechanisms underlying AALD …

T cells become dysfunctional when they encounter self antigens or are exposed to chronic
infection or to the tumour microenvironment 1 . The function of T cells is tightly regulated by a …

Hepatocellular carcinoma (HCC) exhibits cellular heterogeneity and embryonic stem‐cell–related
genes are preferentially overexpressed in a fraction of cancer cells of poorly …

Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To
explore the underlying immune regulators, we examine the microenvironment in glioma and …

Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers.
While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 …

Background Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis
(CP) in males that may cause abnormal urination, sexual dysfunction, or depression and …

Highly malignant human gliomas overexpress the G-protein–coupled chemoattractant receptor
formyl peptide receptor (FPR1), which promotes tumor progression when activated. Our …